Contatto
Come acquistare
Consegna
Guida all'acquisto
Inglese
160 b
30 giorni per il reso
I clienti hanno acquistato anche
In this work we characterize a novel histone lysine §mono-methyltransferase called Setd6. By enzymatic §assays we demonstrate that this protein is capable §of modifying histone H1, H2A, H3 and H4. For all but §the linker histone H1 we furthermore determine the §exact residue methylated. In mouse NIH 3T3 cells a §reduction of the Setd6 protein level leads to a §misregulation of a set of genes including several §that are important for the regulation of §differentiation and cell line commitment. Amongst §those is a segregated co-regulator of the Wnt §signaling pathway. In immunoprecipitation §experiments we identify specific interactors of §Setd6 in murine immortalized fibroblasts and murine §embryonic stem cells. Again we find proteins that §are important for the Wnt signaling pathway. Taken §together the enzymatic activity and the in cell §results we conclude that we identified a novel §histone lysine mono-methyltransferase possibly §involved in the maintenance of cell line identity §and acting as antagonist of the histone §acetyltransferase Tip60 as both enzymes target the §exact same residues.
Informazioni sul libro
Inglese
Regala questo libro oggi stesso
È facile
1 Aggiungi il libro al carrello e scegli la consegna come regalo 2 Ti invieremo subito il buono 3 Il libro arriverà all'indirizzo del destinatarioPotrebbe interessarti anche
Ciao! Sono Libroamiko, il tuo consulente di libri.
Come posso aiutarti?