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The scope of the Special Issue includes developing multimodal machine learning, a subfield of machine learning that works on the development and training of models to leverage the potential of various data sources-genomic, proteomic, imaging data-to improve their predictability performance. It has the advantage of being able to integrate different data modalities. For example, imaging data can be converted into data in sound form to enable earlier systems to differentiate between malignant and benign lesions more effectively. This integration of multimodal clinical data into a cohesive AI model represents a significant step toward making more holistic representations of clinical data. In addition to AI's role in integrating multimodal data, there is a fundamental shift toward using quantitative digital data in clinical research, leveraging the massive amounts of biomarker data generated worldwide. AI has been identified as uniquely capable of combining vast datasets from genomics, proteomics and other 'omics' technologies. This shift enables the establishment of novel therapies and predictive models of drug response, moving beyond the concept of a single biomarker to utilizing combinations of biomarkers for enhanced diagnostic accuracy and treatment decisions. These breakthroughs reinforce the critical role of AI and machine learning in enhancing understanding and capacity toward the proper diagnosis and treatment of diseases. These are necessary in an era of precision medicine, in which data-driven insights steer health solutions into more accurate and effective directions.
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