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Cellular Mechanisms of Hippocampal LTP and LTD Learning and Memory
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Processes of functional plasticity, i.e. long-§lasting changes of the strength of synaptic §connectivity in response to relative short-lasting §afferent stimulation, are the most likely mechanisms §underlying memory storage in the adult brain. The §best studied models of functional plasticity are §long-term potentiation (LTP) and long-term §depression (LTD). Rolipram, a specific type IV-§specific cAMP phosphodiesterase (PDE) inhibitor, was §used in my initial studies to investigate its effect §on late plastic events during functional CA1 §plasticity in rat hippocampal slices in vitro. In §the later part of my studies, I was interested to §investigate the question of what exactly is the §putative nature of the synaptic tag. Are there §specific tags for LTP and LTD?
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