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The use of cells for the treatment of a variety of diseases is no longer a dream. Today, blood transfusion, bone marrow transplantation, the use of ex vivo cultured skin in wound healing, and peripheral stem cell transplantation, including the ex vivo expansion of hematopoietic stem cells after high-dose chemo/radiation therapy, are routine. This high standard of knowledge and skills in cell transplantation might also result in tackling hitherto untreatable diseases. Organ transplantation is presently the only life-saving treatment for a variety of conditions. Important findings in cell and molecular biology could make cellular therapy an alternative to organ transplantation in certain diseases.