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This§comprehensive volume explores human genetic engineering its pre-clinical and§clinical applications, current developments, and as treatment for hereditary§diseases. It presents and evaluates the most recent advances in the§understanding of mammalian host DNA repair mechanisms, such as double-strand§break induced gene targeting and mutagenesis, the development of zinc-finger§nucleases, genome editing for neuromuscular diseases, phase integrases, triplex§forming oligonucleotides and peptide nucleic acids, aptamer-guided gene§targeting, AAV gene editing via DSB repair, engineered nucleases and§trinucleotide repeat diseases, and creation of HIV-resistant cells. The§expertly authored chapters contextualize current developments within the§history of genome editing while also discussing the current and potential§safety concerns of this rapidly growing field.§§Genome Editing: The Next Step in Gene Therapy , the latest§volume in the American Society of§Gene and Cell Therapy series,§deftly illuminates the potential of genetic engineering technology to eradicate§today's deadliest and most prolific diseases. It is ideal reading for§clinicians and researchers in genetics and immunology. §§
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