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Histone Recognition

Name: Histone Recognition
Brand: Springer International Publishing AG
SKU: 15194239
Price: 107.29 EUR
Availability: InStock
Author: Ming-Ming Zhou
ISBN: 9783319376660

Ming-Ming Zhou

Lingua

Inglese

Libro In brossura

Codice Libristo: 15194239

Casa editrice Springer International Publishing AG, ottobre 2016

This book provides a timely review of the role of histone modifications in epigenetic control of gen... Descrizione completa

Codice Libristo: 15194239

263 b

107.29 €

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This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.