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Nisin Based Lantibiotic Engineering

Name: Nisin Based Lantibiotic Engineering
Brand: LAP Lambert Academic Publishing
SKU: 06956260
Price: 41.59 EUR
Availability: InStock
Author: V. Mohanasrinivasan
ISBN: 9783659254734

A novel approach on biopreservation

V. Mohanasrinivasan

C.Subathra Devi

Suganthi V. Selvarajan E.

Lingua

Inglese

Libro In brossura

Codice Libristo: 06956260

Casa editrice LAP Lambert Academic Publishing, novembre 2011

Lantibiotics are ribosomally synthesized polycyclic peptide containing unusual amino acids, which ha... Descrizione completa

Codice Libristo: 06956260

102 b

41.59 €

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Lantibiotics are ribosomally synthesized polycyclic peptide containing unusual amino acids, which have binding specificity for bacterial cells, targeting the bacterial cell wall component lipid II to form pores and there by lyses the cell. Nisin is the one of the most studied commonly used lantibiotics. Nisin inhibit the growth of bacteria by inhibiting cell wall synthesis via binding to Lipid II. Nisin have thio esters five ring system. But first three are actively involved in antimicrobial activity. These are binding to pyrophosphate moiety of lipid II. This mode of action is the rationale for design of small nisin derived peptide to obtain novel potential lantibiotics. As conformational constraints the Thioether Bridge was mimicked by alkanes or alkenes by ring closing metathesis.