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Pharmacogenetic study during chronic myeloid leukemia

Name: Pharmacogenetic study during chronic myeloid leukemia
Brand: LAP LAMBERT Academic Publishing
SKU: 48227185
Price: 34.19 EUR
Availability: InStock
Author: Fatma Turki
ISBN: 9786208424886

Fatma Turki

Rim Frikha

Lingua

Inglese

Libro In brossura

Codice Libristo: 48227185

Casa editrice LAP LAMBERT Academic Publishing, febbraio 2025

Our study aimed to investigate the association between multidrug resistance (MDR1) C1236T, C3435T an... Descrizione completa

Codice Libristo: 48227185

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34.19 €

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Our study aimed to investigate the association between multidrug resistance (MDR1) C1236T, C3435T and G2677T/A polymorphisms and the response to imatinib (IM) in chronic myeloid leukemia (CML).In total, 37 studies were initially identified, and 17 studies, involving 2219 CML patients, were included in this meta-analysis. A significant resistance was found for the C3435T variant in the Caucasian population under dominant and heterozygous models and for the wild type (G2677) in Asian population under all models except heterozygous. However, never significative association was found between IM response and the MDR1 C1236T polymorphism.The MDR1 C3435T polymorphisms might be a risk factor for resistance to IM in Caucasian CML patients.