Practical Process Research and Development

Practical Process Research and Development: A Guide for Organic Chemists, Third Edition provides a concise, comprehensive, step-by-step framework to support understanding and implement organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. The book describes the steps taken following synthesis and evaluation to bring key compounds to market in a cost-effective manner. Through a hands-on, step-by-step approach to solving process development problems, including route, reagent, and solvent selection, optimizing catalytic reactions, chiral syntheses, and green chemistry, this book helps organic, medicinal, pharmaceutical, and chemical process development chemists as well as chemical engineers with research and development initiatives.

In addition, it is well suited for beginners at upper undergraduate and graduate student level and early career researchers who need accessible insights into industrial process R&D.

• Reflects the current thinking in chemical process R&D for small molecules
• Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of small molecules
• Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations, and more
• Presents guidelines for implementing and troubleshooting critical processes
• Includes various problem sets, providing readers with the opportunity to reflect on the course material and real-life situations
• Provides a framework for practical chemical process development for those new to the industry
• Includes examples to aid researchers who have been conducting industrial process R&D