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SHORT AND LONG-TERM EFFECTS OF MDMA EXPOSURE IN RODENTS

Name: SHORT AND LONG-TERM EFFECTS OF MDMA EXPOSURE IN RODENTS
Brand: VDM Verlag Dr. Müller
SKU: 06827200
Price: 67.89 EUR
Availability: InStock
Author: Maria Elena Reveron
ISBN: 9783639190922

SHORT AND LONG-TERM EFFECTS OF MDMA EXPOSURE IN RODENTS: PHYSIOLOGICAL, BEHAVIORAL AND NEUROCHEMICAL RESPONSES

Maria Elena Reveron

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Inglese

Libro In brossura

Codice Libristo: 06827200

Casa editrice VDM Verlag Dr. Müller, novembre 2008

3,4-methylenedioxymethamphetamine (MDMA) is a popular abused amphetamine among young adults. The p... Descrizione completa

Codice Libristo: 06827200

166 b

67.89 €

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3,4-methylenedioxymethamphetamine (MDMA) is a popular abused amphetamine among young adults. The possibility that MDMA intake may be neurotoxic in humans led to a wealth of studies that demonstrated large doses of MDMA cause damage to serononin (5-HT) nerve terminals in rats and non-human primates. However, the exact mechanism of MDMA induced neurotoxicity in animals is unknown. The neurochemical and thermal changes associated with experimenter-delivered repetitive doses of MDMA in mice of two different age groups were investigated.The data suggest older mice are more sensitive to the toxic effects of MDMA and that hyperthermia might contribute to MDMA neurotoxicity.Few studies have examined MDMA effects using drug self-administration procedures. MDMA-stimulated lever responses, locomotor activity, thermal effects, in vivo changes in nucleus accumbens (NAcc) DA and 5-HT levels and post-mortem tissue content of DA, and 5-HT were determined after various periods of MDMA abstinence in MDMA-naďve animals, and those selfadministering over 20 daily sessions. In general, experience- dependent changes in MDMA were observed in all assessed measurements.