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This book constitutes the proceedings of First International Workshop, TML4H 2023, in Kigali, Rwanda, in May 2023.The 16 full papers included in this volume were carefully reviewed and selected from 30 submissions. The goal of this workshop is to bring together experts from academia, clinic, and industry with an insightful vision of promoting trustworthy machine learning in healthcare in terms of scalability, accountability, and explainability.